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Diagnosis Synopsis
Tularemia is caused by Francisella tularensis, an aerobic gram-negative coccobacillus. Tularemia is ubiquitous in the northern hemisphere between 30 and 71° N latitude. Some 100 species of wild mammals, 25 species of birds, several species of fish and amphibians, and more than 50 arthropods have been found to be naturally infected. Humans are extremely susceptible. Humans acquire the infection either after direct contact with the bodily fluids of animal carriers or, more significantly, through ticks and deer flies. Water contaminated by voles, beavers, and muskrats has been responsible for outbreaks. Laboratory workers and farm workers may be at risk of infection from aerosolization. A number of cases spread by cat bites have been reported. Person-to-person transmission is not known to exist.

The CDC has classified tularemia as a Class A bioterrorism agent due to its ease of dissemination, morbidity, and ability to infect with as few as 10 bacterial organisms. The former Soviet Union developed weaponized antibiotic- and vaccine-resistant strains of F. tularensis. F. tularensis is so infective that exposure to an open culture plate can cause human infection. Tularemia is not directly contagious person to person. Aerosol dissemination of F. tularensis has been projected to result in the abrupt onset of large numbers of cases of acute non-specific febrile illness with pleuropneumonitis as the predominant finding.

Tularemia has an extremely variable presentation. The incubation period may range from a few hours to 21 days with a mean of 4.5 days. Typically, a patient has an abrupt onset of fever, headache, chills and rigors, myalgia (especially the low back), coryza, and sore throat. In 42% of patients, a pulse-temperature dissociation has been observed. The cough may be dry or slightly productive, and there may be substernal pain or tightness. Signs of pneumonia may or may not be obvious. Nausea, vomiting, and diarrhea may also occur. F. tularensis usually produces a marked reaction at the portal of entry. This has led to 7 major clinical patterns: glandular, ulceroglandular, oculoglandular, typhoidal, pneumonic, oropharyngeal, and septicemic. Any form of tularemia can be complicated by hematogenous spread resulting in secondary pleuropneumonia, sepsis, or meningitis (rare).

Post-exposure prophylaxis is not recommended for inhalational tularemia due to the short incubation period and incomplete protection of current vaccines. A live attenuated vaccine derived from the avirulent Live Vaccine Strain (LVS) has been used to protect laboratory personnel handling F. tularensis. Isolation is not recommended for tularemia patients due to the lack of human-to-human transmission, although, because of the risk of secondary arthropod transmission, ambient ticks, fleas, lice, and mosquitoes should be controlled.

Tularemia is present throughout the US but is most prevalent in MO, AR, OK, TX, VA, MA, CA, and TN. Prevalence is greatest from June through August (more tick-related infections) and in the fall (during hunting season).

Hunters, game wardens, trappers, and campers are particularly susceptible. Animals known to have transmitted tularemia include rabbits (most common), foxes, squirrels, skunks, muskrats, beavers, voles, and even fish. Other routes of infectivity include contact with contaminated water or mud and aerosol droplets.

Look For
GI symptoms (diarrhea, pain) may be the most prominent feature. Systemic symptoms and signs are seen without lymphadenitis or cutaneous or mucosal lesions.

Ulceroglandular (70-80%):
Papule appears at the inoculation site, most commonly in the inguinal or axillary site. The papule eventually becomes pustular and then ulcerates within a few days. An eschar may or may not form at the inoculation site. There is typically regional lymphadenopathy; the nodes may become fluctuant and rupture.

Oculoglandular (1-5%):
This form results in a purulent conjunctivitis. Small yellow nodules develop on the conjunctiva and ulcerate and are usually unilateral. This may be accompanied by severe eyelid edema, vasculitis, and regional lymphadenitis.

Glandular (10-15%):
The glandular form is characterized by lymphadenopathy without cutaneous manifestations. It is identical to the ulceroglandular type except that a primary lesion cannot be identified.

The oropharyngeal form can present with stomatitis or an exudative pharyngitis or tonsillitis. There also may be ulcers and cervical lymphadenopathy. It may present with cervical nodes resembling the "bull neck" of diphtheria.

This form is rare in naturally acquired infection. Lymphohematogenous spread is the usual pathogenesis. Symptoms include dry cough, pleuritic chest pain, and dyspnea. Signs include rales and pleural friction rubs, pharyngitis, and hilar lymphadenitis along with other signs of systemic illness. X-ray or CT may show bronchial infiltrates, pleural effusions, and hilar lymphadenopathy.

This is the most severe form of tularemia. In addition to the GI presentation of the typhoidal form, CNS symptoms such as confusion or coma may occur.

Medical Disclaimer:
The information contained in this Web page is intended to be an adjunct to traditional medical information sources. It is not intended to be a substitute for professional medical judgment.

Authors and Editors:
Alex Garza, MD