Prolonged or repeated exposure to light. Projectors, light tables and florescent lighting all work to adversely affect the dyes in film.
Improper storage materials. While notebook pages are a convenient way to store slides, not all plastic sleeving is considered safe and archival. PVC (polyvinyl chloride) is not stable and can emit a damaging acid as it deteriorates. Unfortunately, this material is still being manufactured for the purpose of storing photographs and many collections are currently deteriorating as a result.
Grouping images by wrapping them with rubber bands or tapes can cause permanent, irreversible damage to slides. Tapes can stain slide mounts and leave an adhesive residue on the film base that is difficult to remove and rubber bands bend and distort both the mount and film.
Careless handling. It is very difficult to safely remove fingerprints and other accretions (foreign matter adhered to the film) like dust and dirt. A fingerprint is oil-based and will accumulate dirt that will eventually harden and become very difficult to remove. Although film and emulsion cleaners are available for purchase, they can leave a foggy residue on the film. Wiping a slide in an attempt to eliminate either the fingerprint or the residue can easily scratch the image and cause irreversible damage.